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In this process, excessive degradation of aggrecan and Col II leads to NP dehydration and resorption and a decline in the ability of the cells to resist mechanical loading, thus contributing to IDD progression 92,93

To produce S-less No S VLPs, the S expression plasmids were replaced with empty vector plasmids

Cell killing by arachidonate could not be rescued by fer-1, liproxstatin or deferoxamine, highlighting an important distinction between the activity of conjugated and non-conjugated PUFAs (Supplementary Fig

Himmelfarb J, Stenvinkel P, Ikizler TA, Hakim RM (2002) The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia