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The mechanisms behind B12 deficiency in metformin users are multifactorial but are probably related to intestinal absorption, so it seems sensible to assume that oral B12 replacement may be less effective, although there is little evidence in this area
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The patients who respond best to tesamorelin share several characteristics: High visceral fat: The stubborn abdominal fat that sits deep around the organs, not subcutaneous fat just under the skin
doi:10.1080/09513590.2022.2047171