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doi:10.1155/2013/470975 Fiore C, Eisenhut M, Krausse R, et al

One aspect of this study that may be missed are the overall excellent responses achieved with only a moderate dose of methotrexate, highlighting the potency of methotrexate as a DMARD which can often be overlooked in clinical trials that typically enroll only subjects with inadequate responses to methotrexate

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These antibodies destroy the intrinsic factor proteins, making B12 absorption impossible
