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2024) and a leading cause of end-stage renal disease (ESRD) (Xuan et al
This finding is supported by a recent meta-analysis, which showed that plasma glycine concentration is consistently lower in patients with obesity and T2DM compared to healthy individuals (11 and 15%, respectively) [72]
GONZALEZ-CABEZAS, Indiana University School of Dentistry, Indianapolis, IN 24
(2) Preclinicalclinical disconnect: dosing regimens (e.g., colchicine microneedles) lack human PK/PD validation, while transdermal hydrogels need human skin permeability studies to address species-specific stratum corneum variability
