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Description
MPNSTs of the extremities have superior outcomes compared to other disease sites, most likely secondary to an enhanced ability to achieve R0 resections and improved tumor control [49]
Upper limits
One patient survived for 18 months without treatment [8] whereas another died a few months after total resection of a brain metastasis[9]
Skin mast cells carry MRGPRX2, a receptor that fires on cationic, aromatic ("cationic amphiphilic") molecules and releases histamine redness, swelling, the classic wheal. It is confirmed for SS-31, which activates the receptor well below its injection concentration
