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In contrast T2-low neutrophilic asthma is strongly associated with IL 17 TNF- and IL 6 as well as high oxidative stress and corticosteroid resistance
The most notable concern for long-term use is a potential decrease in zinc levels

OS has been recognized as a potential causative factor for diabetes (Maritim et al., 2003

Similar effects were observed in the colon of mice fed a mildly deficient Se diet (Reference Kipp, Banning and van Schothorst28)
