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Protective effect of black seed Nigella sativa L against cyclophosphamide-induced toxicity on reproductive and acrosomal function in mice

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Intranasal administration of the optimized formulation (Cmax = ~ 600 ng/mL, tmax = 0.5 h) exhibited a plasma AUC 0.78 times the AUC of the orally administered product (Cmax = ~ 780 ng/mL, tmax = 2 h), whereas the brain AUC was significantly (3.28 times) higher for intranasal administration (Cmax = ~1240 ng/mL, tmax = 0.5 h) than oral administration (Cmax = ~ 380 ng/mL, tmax = 1 h)