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The apoptosome activates caspase 9, which activates effector caspases, leading to the completion of apoptosis (Fig
Expert Review of Neurotherapeutics
29 Flumazenil has been posed as an alternative in HE because of its anti-GABAergic activity, but a meta-analysis recently published does conclude neither in mortality decrease nor in clinical improvement in patients with HE
These findings have been questioned by more recent studies such as the relatively small MOXI trial
