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identified mitophagy as an intrinsic vulnerability in CRC cells subjected to statin treatment, revealing how disruption of mitochondrial homeostasis, shaped by distinct metabolic contexts, leads to cell death and therapeutic sensitivity [103] Spatial heterogeneity across colorectal tumor sites underlies distinct metabolic phenotypes [104]

Cancer 2015, 67 (7), 10831092

In vivo experiments in 4-5 months old albino strain rats (Charles Foster rats) with these compounds exhibited significant reversal of cognitive deficits as amnesia, compared to treatment with the standard drug donepezil