glutathione conjugation enzyme Simplified scheme of action of the enzymes S-transferases Phase II Reactions - Biotransformation
Description
GSH exists at a concentration of 110 mM in cells and shows a K m of 8 mM and a k cat / K m of 1.6 10 4 M -1 s -1 in the SQOR-catalyzed reaction ( FIGURE 9 For many years, no selective small-molecule inhibitor of SQOR was known, which limited pharmacological studies of this enzyme
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This systemic action is what makes timing so important
However, the specific mechanisms remain unclear due to multiple interacting factors such as cyclical gene expression, cell-cell interactions, follicular microenvironment variability, oxidative stress, and external stimuli
