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The samples were homogenized to allow for centrifugation of the supernatant, followed by measurement of AngIV, TNF-alpha, IL-10, and IL-1-beta levels through the use of a sensitive and specific ELISA assay
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The results showed that reduced GFR was the only factor associated with high dabigatran concentration, regardless of which formula was used (ORs for CrCL, CKD-EPI and MDRD, 0.95 [0.92, 0.99], p = 0.02, 0.94 [0.91, 0.98], p = 0.002, and 0.96 [0.93, 0.99], p = 0.01, respectively)
