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To understand the role of mitochondrial ROS, the organelle-targeted antioxidants [83] seem to be almost the exclusive tool, as it is not possible to inhibit the mitochondrial ROS-producing electron transport chain without affecting mitochondrial ATP production, calcium uptake, and metabolic functions

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This complex is then directed to the lysosomes, degraded, and free B 12 is then transported into the cytosol (Figure 2) [28]