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Description
Two or more of the DSM-5-TRs 11 stimulant use disorder criteria

The extracellular matrix proteins decorin, perlecan, and biglycan have all been reported as upregulated targets

The treatment involves drawing a blood sample, processing it to concentrate the platelets, and injecting the platelet-rich plasma into the shoulder joint

Relative contraindications requiring careful consideration and enhanced medical supervision include history of pancreatitis, severe gastrointestinal disease including gastroparesis, diabetic retinopathy (requires ophthalmologic monitoring during therapy), severe kidney disease, history of suicidal ideation or severe depression, gallbladder disease or history of cholecystitis, and age under 18 years
