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For example, cultured astrocytes subjected to oxygen and glucose deprivation showed a decrease in mitochondrial membrane potential, possibly caused by the mitochondrial permeability transition pore (mtPTP) opening, which leads to a loss of intramitochondrial contents, mitochondrial respiration and ATP production [48]

Overexpression of SIRT3 decreases HCC cell proliferation and promotes apoptosis through multiple mechanisms, including the activation of the GSK-3/Bax signalling pathway [196], upregulation of p53 [198], and reduction in Mdm2-mediated p53 degradation [199]

In Chemically Modified Bodies: The Use of Diverse Substances for Appearance Enhancement