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14 Additionally, in gastric cancer cells, NSUN2 lactylation at lysine 508 facilitates GCLC mRNA m 5 C, increasing GSH production and lipid peroxidation inhibition and ultimately inducing ferroptosis resistance

Although these direct antioxidant effects are observable in vitro, their significance in vivo appears limited, stemming from low plasma concentrations of NAC and the prevalence of more abundant endogenous antioxidants such as GSH, ascorbate, and antioxidant enzymes (e.g., SODs, GPs, CAT) [6,38,39]

Without any clear rationale, the study outcome measures were purposefully modified midtrial to alter the findings in favour of their hypothesis (549, 550)