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Inside these cells nitric oxide activates guanylate cyclase, which increases cyclic GMP levels

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Unlike the canonical ferroptosis pathway due to GPX4 inactivation, intracellular Fe 2+ accumulation, which can react with peroxides in the Fenton reaction, generates excess hydroxyl radicals, induces lipid peroxidation, and drives cellular ferroptosis [117, 118]

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Farrigan c, Pang k

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Pyper E, McKeown S, Hartmann-Boyce J, Powell J

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