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TB-500: Notch Signaling Angiogenesis & Differentiation Studies suggest TB-500 promotes angiogenesis likely through the Notch signaling pathway, which regulates cell fate decisions and vascular development[5]

It regulates mitochondrial activity through modulation of transcription factors and is a crucial cofactor in the -oxidation of fatty acids, which facilitates the cellular energy production process (Sahebnasagh et al., 2022), balancing hypertonicity-induced imbalances between oxygenase and antioxidant enzymes, reducing ROS production, inhibiting lipid peroxidation, preventing oxidative DNA damage, and suppressing the production of heme oxygenase-1 and cyclooxygenase-2

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In our study, selective IP6K inhibition by SC-919 decreased cellular InsP 7 levels and phosphate export