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In Small JE, Noujaim DL, Ginat DT, Kelly HR (eds.)

Additionally, it was demonstrated, that failure PINK/PARKIN axis expression favors the accumulation of defective mitochondria that are not removed from the cells due to the impaired lysosomal system which in consequence promotes cellular damage, generates oxidative stress, and impairs sensitivity for insulin [60]

When you are deficient in vitamin B-12, it is possible to become anemic
Accordingly, the mechanistic link between lactate-mediated pH changes and iron-dependent ferroptosis remains inadequately characterized
