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Description
Comparative studies on insulin-like growth factor II and insulin processing by vascular endothelial cells
Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability
The basic strategy is to obtain a reagent focusing its activity prevalently around the cells expressing CD38, which enables avidity-induced blocking of CD47 on the same cells, in this way avoiding unwanted off-tumor effects
While hGH did produce a slight increase in glycerol in the knockout mice, the response was markedly lower than in WT animals
