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CrossRef Sex-Biased Molecular Signature for Overall Survival of Liver Cancer Patients Sun Young Kim, Hye Kyung Song, Suk Kyeong Lee, Sang Geon Kim, Hyun Goo Woo, Jieun Yang, Hyun-Jin Noh, You-Sun Kim, Aree Moon Biomolecules & Therapeutics.2020

Both enzymes are present in the cytoplasm and mitochondrial matrix in different forms

When NRX is oxidized by NADPH oxidase 1 (NOX1)-derived H2O2 or lipid peroxide (ROOH), DVL is released and inhibits glycogen synthesis kinase 3 (GSK3) in the -catenin degradation complex, thereby stabilizing the -catenin in the cytoplasm and partially entering the nucleus to activate the target gene GPX2 by correlation with the TCF/LEF transcription factor family (Kipp et al., 2012) (Figure 2)

Augmenter of liver regeneration improves therapeutic effect of hepatocyte homotransplantation in acute liver failure rats