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Normally, the transcription factor Nrf2 and its inhibitory protein KEAP1 are tightly bound to inhibit activity, but in the presence of ROS, a conformational change in KEAP1 results in the release of NRF2, which binds to the antioxidant response element (ARE) and activates the downstream genes heme oxygenase-1 (HO-1), glutathione peroxidase 4 (GPX4), quinone oxidoreductase1(NQO1), thioredoxin reductase 1 (SRXN1), and transcription of solute carrier family 7 member 11 (SLC7A11), which enhance cellular antioxidant defenses and inhibit ferroptosis (Wang et al., 2022

Redox homeostasis and antioxidant signaling: a metabolic interface between stress perception and physiological responses

So, while the explanation touches on real aspects of neuropathy and B12 deficiency, it might oversimplify or misrepresent some of the complex interactions in the nervous system

434 CRaf interacts with MEK through the phosphorylation of active sites (Ser338 and Tyr341)