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Therapeutic modulation of this balance is emerging: for example, overexpression of Angiotensin-Converting Enzyme-2 (ACE2) shifts microglia toward the protective M2 phenotype, reducing dopaminergic neurodegeneration

Diabetic peripheral neuropathy: prevention and treatment

Confounding by supplement excipients: many nutrient supplements [e.g., calcium carbonate (221), zinc gluconate (254)] contain excipients [e.g., lactose, maltodextrin] that can independently alter gut microbiota composition

Because safety hasn't been established, the standard advice is to skip it while pregnant or nursing unless a doctor says otherwise (WebMD)