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Mutations impairing the function of the OCTN2 transporter result in carnitine deficiency that can present early in life with hypoketotic hypoglycemia, or later in life with cardiomyopathy and sudden death from cardiac arrhythmia

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Aortic rings (1.52 mm in length) were mounted on a wire myograph (Danish MyoTechnology, Aarhus, Denmark) filled with KHS

In the current study, we performed an integrated investigation of targeted and non-targeted metabolomics in plasma collected at various time points after MA self-administration, subsequent extinction, and reinstatement with a priming injection of MA to elucidate the dynamic metabolic changes associated with the progression of drug dependence