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Keratinocytes deposit the incorporated melanin (a polymerization product from tyrosine) above the nucleus (supranuclear) to protect the genetic material from UV rays

Results Cryo-EM structure determination of OCTN2 To determine the structure of OCTN2, we overexpressed full-length human OCTN2 in HEK293F cells and isolated the transporter using a GFP-nanobody purification strategy 28

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