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Investigations into whether the association between low folate levels and impaired DNA biosynthesis, rather than impaired DNA methylation, was the underlying cause of malformations in early embryogenesis were also made but have not conclusively demonstrated a clear link to NTDs in humans [251]
In GPX5-gene KO mice, sperm DNA damage is significantly increased, while an 8-weeks pretreatment of GPX5 KO mice using antioxidants completely protects sperm DNA from oxidative stress damage ( 2.6 GPX6 Glutathione peroxidase 6 (GPX6), also known as olfactory organ glutathione peroxidase ( It is believed that GPX6 is mainly expressed in embryonic and olfactory organ epithelial cells, and may be involved in the transmission and degradation of odor-related signals
doi: 10.1016/j.biortech.2023.130093 108 JockersRDelagrangePDubocovichMLMarkusRPRenaultNTosiniGet al
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