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This conformation of KEAP1-NRF2 complex allows an adequate Lysine (Lys) rich -helix orientation in the Neh2 domain for KEAP1-dependent polyubiquitination [157]

Stegen S, van Gastel N, Eelen G, Ghesquiere B, D'Anna F, Thienpont B, Goveia J, Torrekens S, Van Looveren R, Luyten FP, Maxwell PH, Wielockx B, Lambrechts D, Fendt SM, Carmeliet P, and Carmeliet G

However, a growing body of evidence reveals a pronounced immunoinflammatory phenotype in OA, wherein macrophages, T/B lymphocytes, and inflammatory factors such as IL-1, TNF-, and IL-6 play a critical role in the local microenvironment (105)