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In totality, our findings indicate that NSCLC cells sustain their respiratory capacity in response to cysteine deprivation to the detriment of their viability

However, their clinical translation is limited by challenges in intracellular delivery to target cells and the potential for off-target gene silencing effects in non-target tissues

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Principal component analysis (PCA) and t-distributed stochastic neighbor embedding (t-SNE) were performed utilizing the Rtsne (version 0.16) and stats (version 4.1.1) R packages to assess the distribution of various groups