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To produce models to investigate LHON, researchers have generated iPSCs with mutations in the MT-ND4 gene (G11778A) to differentiate neurons and retinal ganglion cells (Yang et al., 2020
The transamination of KG produces Glu and, dependent on the amino acid, a keto-acid (Fig
Creatine is vital for mitochondrial energy buffering it stores and transfers phosphate groups that recycle ATP, the cells main energy currency
