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Edited by: Shils ME OJASM

Glutathione (GSH, L--glutamylcysteinylglycine) is a crucial metabolite in eukaryotes and plays a major role in protecting cells against oxidative damage 20

A landmark observational study found that glutathione deficiency (measured as low cysteine levels) was an independent predictor of 2-year survival in HIV patients [38]

1c emphasises APX-dependent removal of H 2 O 2 , other ROS such as superoxide may also chemically oxidize both ascorbate and glutathione (Polle 2001)
