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Constitutive MECP2 knockout (KO) mice, designed to study MECP2 loss, exhibit severe neurological symptoms such as uncoordinated gait, hindlimb clasping, and irregular breathing after an initial period of normal development (111, 112)

[DOI] [PMC free article] [PubMed] [Google Scholar] 126.Fullmer M.A., Abrams S.H., Hrovat K., Mooney L., Scheimann A.O., Hillman J.B., Suskind D.L

Studies have indicated that the fundamental characteristics of ferroptosis, including increased lipid peroxidation, the depletion of GSH, the inactivation of GPX4 and elevated iron deposition, are manifested in the inflamed intestinal tissue of patients with IBD and in animal models of IBD (19,58,59)

[DOI] [PMC free article] [PubMed] [Google Scholar] 83.Nash TP, Benedict SR