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They can deliver a normal copy of a mutated (target) gene or knock out a causative gene by targeting its RNA [203]
MSH also reduced activation of fibroblasts, as measured by SMA staining (179) or IL-1-induced IL-8 release (181), as well as it conferred cytoprotection under inflammatory stimuli like IL-1, LPS and TNF- (180)
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S1 ), suggesting the effect is specific for DNA damaging agents
