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Furthermore, metformin stimulates insulin signaling and glucose transport in muscles while inhibiting critical enzymes involved in gluconeogenesis and glycogen production in the liver when the enzyme adenosine monophosphate kinase (AMPK) is activated[7,25,26]

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The upregulation of Srf directly controls the immediate early gene response and is an essential regulator of neuronalactivityinduced gene expression (Knoll & Nordheim, 2009)

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Enhancing Antioxidant Defenses: By bolstering the cell's natural antioxidant systems, MOTS-c helps to neutralize harmful free radicals, protecting cells from oxidative damage

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