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Leu244 at the 2 nd activity controller position of jr PPO1-wt was mutated to a positively charged arginine (Leu244Arg), leading to a decrease of the k cat values for mono- and diphenolic substrates by 15-fold for tyramine, 4-fold for dopamine and 11-fold for L -DOPA in comparison to jr PPO1-wt (Table 2)

Moreover, up-expression of GSTA was suggested to protect liver cells against oxidative stress via an extracellular signal-regulated kinases (ERKs) and p38 kinase (p38K)-related pathway, as well as through the inhibition of H2O2-induced apoptosis to inhibit reactive oxygen species (ROS)- induced lipid peroxidation

doi: 10.1007/s11064-016-2011-0, 36

A former Washington University faculty member, Perlmutter succeeds Larry J