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Acknowledgments The authors would like to thank Key Compounding Pharmacy for database access and providing a historical context for the use of intranasal glutathione

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Int J Mol Sci 22(21):11453 Han L, Zhang Y, Zhang M, Guo L, Wang J, Zeng F, Xu D, Yin Z, Xu Y, Wang D, Zhou H (2020) Interleukin-1-induced senescence promotes osteoblastic transition of vascular smooth muscle cells

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N-demethylation of hydrocodone to form norhydrocodone via CYP3A4 while O-demethylation of hydrocodone to hydromorphone is predominantly catalyzed by CYP2D6 and to a lesser extent by an unknown low affinity CYP enzyme

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