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A clarifying question would be if brain metabolites, as measured by MRS, were also altered by exogenous proinflammatory cytokine injection or peripheral immune challenge
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Notably, in a therapeutic combination approach, in a carbon tetrachloride-induced mouse model, combining silybin with GS-9973 (a drug that specifically inhibits SYK kinase in HSCs) produces a synergistic effect, more effectively inhibiting HSC activity, alleviating hepatic fibrosis, and preventing hepatic carcinoma
2019;575(7784):688-692.[DOI] 81
