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Levels in the low-normal range, between 200 and 300, may warrant supplementation even without overt symptoms, particularly in patients with risk factors for deficiency

(PubMed) Curhan GC, Willett WC, Speizer FE, Stampfer MJ

Pan M, Reid MA, Lowman XH, Kulkarni RP, Tran TQ, Liu X, Yang Y, Hernandez-Davies JE, Rosales KK, Li H, Hugo W, Song C, Xu X, Schones DE, Ann DK, Gradinaru V, Lo RS, Locasale JW, Kong M

There is ample evidence to indicate that factors present in the tumor microenvironment (TME), such as products of inflammatory cells reactive nitrogen and oxygen species may cause DNA damage to the neighboring cells, thereby contributing to tumor progression [102]