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Moreover, it has been shown that modest weight loss regulates menstruation, improves reproductive performance and hirsutism, reduces serum androgen and insulin levels and improves the index of insulin sensitivity in women with PCOS [1]

Effect of age, diet, and tissue type on PCr response to creatine supplementation

Based on basic MichaelisMenten enzyme kinetics, by supplying the extra substrate and cofactor (i.e., folate and riboflavin) the reduced affinity can be overcome and the consequences of having the variant can be alleviated, e.g., reduction in elevated homocysteine, reduction in blood pressure, etc. This is the very definition of personalized nutrition, in this case an increased requirement of two essential nutrients based on a common genetic difference
