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Here we developed a sphingolipid-derived PTX nanovesicle (paclitaxome) via covalently conjugating PTX to sphingomyelin, which improved pharmacokinetics and enhanced efficacy in metastatic triple-negative breast cancer and pancreatic cancer female mice and reduced myelosuppression

One adult subject was excluded from the analysis because of a potential dosing error indicated by a significantly higher PK profile following the first dose compared to subsequent doses (peak ratio of first:second dose, 4.05)

for III, where pKa2 was 5.23% higher

Furthermore, the rate of transformation from OSF into oral cancer is above 4% worldwide