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Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: A potential therapeutic target

In normal individuals, IGF-1 can not only be delivered to target tissues by insulin-like growth factor binding proteins (IGFBPs) as a circulating hormone, but also synthesized in target organs, where it exerts actions through paracrine and autocrine mechanisms [8,9]

[DOI] [PubMed] [Google Scholar] 438.Blom AM, Kask L, Ramesh B, Hillarp A

Study Drug and Procedures Participants were required to remain at the study site from the evening of Day 1 until the morning of Day 7
