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The most common inclusion criterion for performing the surgical treatment is that 12 months must have elapsed from the onset of symptoms and evidence of stable curvature for at least 3 months 6

The membrane-associated phosphatidic acid preferring phospholipase A 1 isozymes and act on phosphatidic acid and produce lysophosphatidic acid, which also has multiple biological functions ranging from platelet aggregation and smooth muscle contraction to the stimulation of cell proliferation and motility

J R Soc Interface (2022) 19(193):20220325

This means that a large portion of the ingested supplement is not immediately absorbed into the bloodstream