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335 Quercetin, which targets the Bcl-2 family member hypoxia-inducible factor-1 (HIF-1) and the antiapoptotic PI3K/AKT and p21 signaling pathways, has demonstrated synergistic effects (Table 1)

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Holistic thinking comes first

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Jger R, Abou Sawan S, Orr M, Tinsley GM, Purpura M, Wells SD, et al

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In the future, from a clinical perspective, it will remain increasingly important to identify how melatonin addresses the physiological needs of an individual, taking into account diet, medications, dietary supplements, and lifestyle

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