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335 Quercetin, which targets the Bcl-2 family member hypoxia-inducible factor-1 (HIF-1) and the antiapoptotic PI3K/AKT and p21 signaling pathways, has demonstrated synergistic effects (Table 1)

Holistic thinking comes first

Jger R, Abou Sawan S, Orr M, Tinsley GM, Purpura M, Wells SD, et al

In the future, from a clinical perspective, it will remain increasingly important to identify how melatonin addresses the physiological needs of an individual, taking into account diet, medications, dietary supplements, and lifestyle
