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[DOI] [PubMed] [Google Scholar] 49.Fan X., Monnier V.M., Whitson J

The IPDGC GWAS is also a meta-analysis, aggregating associations across 17 cohorts with individuals of European ancestry

found that environmental factors can enhance KRAS mutation and, further, activate YAP-TAZ-JAK-STAT3 signaling, which is required for the development of ADM ( KRAS mutation synergistically with NOTCH signaling, and these mutations could further promote the conversion of PanIN into PDAC ( Gomes-Filho, S
