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An overview of herbal nutraceuticals, their extraction, formulation, therapeutic effects and potential toxicity

In hepatocellular carcinoma (HCC), curcumin interferes with progression by modulating PI3K/AKT and Wnt/beta-catenin pathways, inhibits PI3K/AKT signaling to downregulate vascular endothelial growth factor (VEGF) expression, suppresses HCC cell proliferation, induces apoptosis of liver cancer stem cells by increasing pro-apoptotic proteins caspase-3, caspase-9, and Bax while reducing Bcl-2, downregulates BCLAF1 to disrupt the PI3K/AKT/GSK-3beta signaling cascade, suppresses beta-catenin activity and the Wnt signaling pathway, activates p38 MAPK to induce FasL synthesis, promotes apoptosis by inhibiting the NF-B signaling pathway, downregulates histone deacetylases, and prevents the transition from NASH to HCC by decreasing oxidative stress and blood glucose levels via downregulation of HMGB1 and inhibition of NF-B nuclear translocation

As defined by the medical community, acne scarring represents permanent changes in the structure of the skin due to damage to the