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The translational potential of AST as a therapeutic and preventive agent is critically evaluated, alongside its pharmacokinetic challenges, bioavailability, and safety profile in aging populations

These exosomes are internalized by macrophages, leading to their activation into a pro-inflammatory M1 phenotype [319]

The study population included patients younger than 18 years at the time of reporting

To correct for this, we performed RNA-seq analysis of hypothalami obtained from animals treated with daily injections of either GLP-1MK-801 or a dose of semaglutide that was equipotent in terms of weight-lowering efficacy over 5 days of treatment, that is, mice had achieved a comparable weight loss and reduction in food intake as that of GLP-1MK-801-treated mice (Extended Data Fig