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This is supported by the observations that: (1) inorganic Hg accumulation in the proximal tubule region of the nephron is mainly handled by filtrationreabsorption as glutathione-Hg conjugates 5,6 , and (2) the renal uptake of glutathione-Hg conjugates occurs mainly at the luminal membrane via a molecular mimicry mechanism using animo acid transporters 9,12

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A meta-analysis of 12 observational studies (5 prospective cohort studies, 4 case-control studies, and 3 cross-sectional studies) also found blood concentrations of selenium to be inversely associated with risk of stroke (94)