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Once activated, reactive astrocytes can exacerbate inflammation, trigger apoptotic pathways in neurons and contribute to A accumulation

The decision framework should prioritize individual health status, specific therapeutic goals, and risk tolerance

A lower paclitaxel dose intensity with the 3-weeks-on, 1-week-off schedule compared with a continuous weekly schedule may compromise anti-tumour activity, although paclitaxel regimens with doses of 70100 mg m 2 administered for 3 weeks of each 4-week cycle have been used in combination with cytotoxic agents in patients with advanced cancers with encouraging evidence of anti-tumour activity and acceptable tolerability (Perez et al, 2005

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