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Moreover, prolonged modulation of synaptic pathways carries potential risks of excitotoxicity and maladaptive plasticity, emphasizing the need for tightly controlled release kinetics
Suzuki R, Fujiwara Y, Saito M, et al
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High NNMT expression is closely associated with glucose dysregulation: excessive NNMT activation disrupts nicotinamide metabolism, lowers NAD+ levels, impairs insulin signaling, reduces cellular glucose uptake and utilization, and promotes hyperglycemia and insulin resistance
