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Subsequent studies revealed the structure of related complexes and demonstrate how F-box proteins bind substrates (see also References 102,127,140)
The primary damaging effect is associated with a profound loss of astrocytic glutamate clearance, leading to excitotoxicity 246,247

Garbuzenko DV (2022) Pathophysiological mechanisms of hepatic stellate cells activation in liver fibrosis

doi: 10.1016/j.tins.2020.04.003
