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Neuropsychiatric effects have been reported in post-marketing surveillance of GLP-1 receptor agonists, though the incidence and causal relationship remain unclear

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Costimulation serves as a mechanism to modulate the strength of the TCR signal and promote higher gene expression of immunomodulatory cytokines like interleukin-2, as well as other factors that facilitate T cell proliferation and differentiation ( A key mediator of T cell signaling is the divalent cation calcium (Ca 2+ )

The results of this study also indicated that supplemental vitamin C may be helpful in the prevention of gout (74)