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Overall, the majority of evidence indicates that NSW significantly contribute to increased oxidative stress and DNA damage, along with diminished DNA repair capacity and altered antioxidant defenses, potentially underlying the elevated health risks, predisposing to several chronic diseases including cancer, observed in NS-working populations 64,69,85,86

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Cyclic deoxyguanosine DNA adducts were formed in a dose-dependent fashion in acrolein-exposed Salmonella typhimurium TA100 and TA104